Detalhe da pesquisa
1.
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
Cell Metab
; 7(1): 68-78, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18177726
2.
Evaluation of [¹8F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.
Neuroimage
; 68: 1-10, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23238431
3.
Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.
Cell Metab
; 4(4): 275-82, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17011500
4.
Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor.
Neuroimage
; 54(4): 2635-42, 2011 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078401
5.
Synthesis, characterization, and monkey PET studies of [¹8F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435.
Synapse
; 65(2): 125-35, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20524178
6.
The synthesis and preclinical evaluation in rhesus monkey of [¹8F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers.
Synapse
; 65(4): 261-70, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20687108
7.
Reducing abuse liability of GABAA/benzodiazepine ligands via selective partial agonist efficacy at alpha1 and alpha2/3 subtypes.
J Pharmacol Exp Ther
; 332(1): 4-16, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19789360
8.
Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.
J Pharmacol Exp Ther
; 332(1): 17-25, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19779131
9.
Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain.
Eur J Nucl Med Mol Imaging
; 37(5): 920-33, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20033684
10.
In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
J Pharmacol Exp Ther
; 331(2): 470-84, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19704033
11.
Inverse agonist histamine H3 receptor PET tracers labelled with carbon-11 or fluorine-18.
Synapse
; 63(12): 1122-32, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19670309
12.
Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects.
J Nucl Med
; 49(3): 439-45, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287275
13.
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
J Med Chem
; 50(15): 3427-30, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608398
14.
Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis.
J Nucl Med
; 48(1): 100-7, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17204705
15.
Screening cascade and development of potential Positron Emission Tomography radiotracers for mGluR5: in vitro and in vivo characterization.
Mol Imaging Biol
; 7(4): 314-23, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16080024
16.
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant.
Biol Psychiatry
; 55(10): 1007-12, 2004 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15121485
17.
A cell-based radioligand binding assay for farnesyl: protein transferase inhibitors.
J Biomol Screen
; 8(4): 430-8, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-14567795
18.
An in vitro assay for predicting successful imaging radiotracers.
Mol Imaging Biol
; 5(2): 65-71, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14499146
19.
Synthesis and characterization of a potent, selective, radiolabeled substance-P antagonist for NK1 receptor quantitation: ([18F]SPA-RQ).
Mol Imaging Biol
; 6(6): 373-84, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15564148
20.
Image-derived input function for [11C]flumazenil kinetic analysis in human brain.
Mol Imaging Biol
; 5(2): 72-8, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14499147